Carbamic acid, [(2S)-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI)
N-BOC-(S)-1-AMINO-2-PROPANOL
CAS: 167938-56-9
Molecular Formula: C8H17NO3
Carbamic acid, [(2S)-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI) - Names and Identifiers
Carbamic acid, [(2S)-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI) - Physico-chemical Properties
| Molecular Formula | C8H17NO3 |
| Molar Mass | 175.23 |
| Density | 1.025±0.06 g/cm3(Predicted) |
| Boling Point | 276.4±23.0 °C(Predicted) |
| pKa | 12.42±0.46(Predicted) |
| Storage Condition | 2-8°C |
Carbamic acid, [(2S)-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI) - Introduction
N-BOC-(S)-1-AMINO-2-PROPANOL(N-BOC-(S)-1-AMINO-2-PROPANOL) is an organic compound. The following is an introduction to some of its properties, uses, methods and safety information:
Nature:
-Appearance: colorless liquid or white solid
-molecular formula: C11H21NO3
-Molecular weight: 215.29g/mol
-Melting point: 55-58 ° C
-Boiling point: 118 ° C (0.4 mmHg)
Use:
- N-BOC-(S)-1-AMINO-2-PROPANOL is a chiral molecule that can be used as a chiral inducer in organic synthesis.
-It is often used as a chiral intermediate for the synthesis of drugs and natural products, especially in pharmaceutical research and biomedicine.
Method:
- N-BOC-(S)-1-AMINO-2-PROPANOL can be prepared by reacting (S)-1-AMINO-2-PROPANOL with a Boc acid carboxy protecting agent.
-The specific preparation method is as follows:
1. The reaction of (S)-l-amino-2-propanol with t-butyl N-hydroxycarbonate yields (S)-tert-butyl 2-hydroxypropylaminocarbinol under base catalysis.
2. Reaction of (S)-tert-butyl 2-hydroxypropylaminomethanol with dimethylformamide (DMF) or acetonitrile to introduce a Boc protecting group in the presence of an HCl solution produces (Boc)2O.
3. (Boc)2O is added into the reaction system to undergo esterification reaction with (S)-tert-butyl 2-hydroxypropylaminomethanol to generate the final product N-BOC-(S)-1-AMINO-2-PROPANOL.
Safety Information:
- N-BOC-(S)-1-AMINO-2-PROPANOL is generally less dangerous under correct operation.
-Should be used in well-ventilated laboratory conditions and wear appropriate personal protective equipment, such as protective glasses and gloves.
-Avoid contact with skin and eyes. If you do, rinse immediately with plenty of water.
-Prevent contact with oxidants and strong acids during use or storage.
-For more detailed safety information, refer to the safety data sheet of the compound.
Nature:
-Appearance: colorless liquid or white solid
-molecular formula: C11H21NO3
-Molecular weight: 215.29g/mol
-Melting point: 55-58 ° C
-Boiling point: 118 ° C (0.4 mmHg)
Use:
- N-BOC-(S)-1-AMINO-2-PROPANOL is a chiral molecule that can be used as a chiral inducer in organic synthesis.
-It is often used as a chiral intermediate for the synthesis of drugs and natural products, especially in pharmaceutical research and biomedicine.
Method:
- N-BOC-(S)-1-AMINO-2-PROPANOL can be prepared by reacting (S)-1-AMINO-2-PROPANOL with a Boc acid carboxy protecting agent.
-The specific preparation method is as follows:
1. The reaction of (S)-l-amino-2-propanol with t-butyl N-hydroxycarbonate yields (S)-tert-butyl 2-hydroxypropylaminocarbinol under base catalysis.
2. Reaction of (S)-tert-butyl 2-hydroxypropylaminomethanol with dimethylformamide (DMF) or acetonitrile to introduce a Boc protecting group in the presence of an HCl solution produces (Boc)2O.
3. (Boc)2O is added into the reaction system to undergo esterification reaction with (S)-tert-butyl 2-hydroxypropylaminomethanol to generate the final product N-BOC-(S)-1-AMINO-2-PROPANOL.
Safety Information:
- N-BOC-(S)-1-AMINO-2-PROPANOL is generally less dangerous under correct operation.
-Should be used in well-ventilated laboratory conditions and wear appropriate personal protective equipment, such as protective glasses and gloves.
-Avoid contact with skin and eyes. If you do, rinse immediately with plenty of water.
-Prevent contact with oxidants and strong acids during use or storage.
-For more detailed safety information, refer to the safety data sheet of the compound.
Last Update：2024-04-09 02:00:51
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Tel: 18301782025
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